Frontiers | VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
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VCAM1 is a 90-kDa glycoprotein belonging to the immunoglobin superfamily and was first identified as an endothelial cell surface glycoprotein (27, 28). Prior studies that have noted the importance of VCAM1 mainly focused on vascular inflammatory diseases and immune diseases (7), we provided the firs
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- VCAM1 is a 90-kDa glycoprotein belonging to the immunoglobin superfamily and was first identified as an endothelial cell surface glycoprotein (27, 28). Prior studies that have noted the importance of VCAM1 mainly focused on vascular inflammatory diseases and immune diseases (7),
- we provided the first evidence of VCAM1 upregulation in CRC tissues compared with adjacent normal tissues. Overexpression of VCAM1 was closely associated with the invasive and aggressive clinical characteristics and poor prognosis of CRC patients.
- A great amount of evidence has shown that VCAM1 is significantly implicated in the metastasis of cancer cells. VCAM1 was overexpressed in lung metastasis compared to primary breast cancer and mediated bone metastasis in mouse and human breast cancer cell lines
- In addition, we showed that VCAM1 regulates the process of TEM in CRC cells. In the progression of invasion and metastasis, it is necessary for tumor cells to cross the endothelial barrier and perform transendothelial migration
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