Frontiers | Promoter Methylation Analysis of IDH Genes in Human Gliomas
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. A salient biochemical feature of cells carrying mutant IDH is increased R-2 hydroxyglutarate (2HG) production via consumption of αKG and NADPH (Dang et al., 2009). we quantified methylation levels within the CpG island associated with the promoter regions of both IDH1 and IDH2 by bisulfite pyroseq
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- . A salient biochemical feature of cells carrying mutant IDH is increased R-2 hydroxyglutarate (2HG) production via consumption of αKG and NADPH (Dang et al., 2009).
- we quantified methylation levels within the CpG island associated with the promoter regions of both IDH1 and IDH2 by bisulfite pyrosequencing.
- s most, if not all, tumor suppressor genes are inactivated by epigenetic silencing, in a wide variety of tumors, we asked if IDH1 or IDH2 carry the epigenetic signature of a tumor suppressor by assessing cytosine methylation at their promoters
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