Frontiers | Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson’s Disease
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integration of metabolomics and epigenetics (genome-wide DNA methylation; epimetabolomics) 48 metabolites to be at significantly different concentrations (FDR q < 0.05), 4,313 differentially methylated sites [5’-C-phosphate-G-3’ (CpGs)] (FDR q < 0.05) and increased DNA methylation age in the primary
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- integration of metabolomics and epigenetics (genome-wide DNA methylation; epimetabolomics)
- 48 metabolites to be at significantly different concentrations (FDR q < 0.05), 4,313 differentially methylated sites [5’-C-phosphate-G-3’ (CpGs)] (FDR q < 0.05) and increased DNA methylation age in the primary motor cortex of people who died from PD.
- Primary bile acid biosynthesis as the major biochemical pathway to be perturbed in the frontal lobe of PD sufferers, and the metabolite taurine (p-value = 5.91E-06) as being positively correlated with CpG cg14286187
- post-mortem (PM) brain from people who died from PD and compared them with age-, and sex-matched controls
- identified 48 statistically significantly differentially expressed metabolites in PD PM brain as compared to controls
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