Frontiers | α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
www.frontiersin.org
Exocytosis is divided into three sequential steps, docking, priming and vesicle fusion. Synaptic vesicles are tethered to specialized regions on the plasma membrane whereby they become stably bound. After docking, the vesicles are primed or matured through a series of ATP-dependent reactions. When a
1 Users
0 Comments
2 Highlights
0 Notes
Top Highlights
- Exocytosis is divided into three sequential steps, docking, priming and vesicle fusion. Synaptic vesicles are tethered to specialized regions on the plasma membrane whereby they become stably bound. After docking, the vesicles are primed or matured through a series of ATP-dependent reactions. When an action potential invades, the voltage-gated Ca2+...
- Collectively, α-Syn plays a critical role in the docking, priming, and fusion steps of exocytosis, probably by serving as a non-classical chaperone that facilitate SNARE assembly (Chandra et al., 2005; Burre et al., 2010, 2014). The mechanism by which α-Syn maintains the presynaptic SNARE complex assembly is the simultaneous binding of α-Syn to the...
Domain
Ready to highlight and find good content?
Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.