Frontiers | Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools
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BH from patients affected by DLB, AD, CJD The Protein-Misfolding Cyclic Amplification (PMCA) and the Real-Time Quaking-Induced Conversion (RT-QuIC) are ultrasensitive protein amplification assays for the detection of misfolded protein aggregates. recently tested for the detection of misfolded α-synu
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- BH from patients affected by DLB, AD, CJD
- The Protein-Misfolding Cyclic Amplification (PMCA) and the Real-Time Quaking-Induced Conversion (RT-QuIC) are ultrasensitive protein amplification assays for the detection of misfolded protein aggregates.
- recently tested for the detection of misfolded α-synuclein in brain homogenates and cerebrospinal fluid samples of patients affected by synucleinopathies
- two ultrasensitive protein amplification methods for detecting pathological protein aggregates in patients affected by protein misfolding disorders
- template (protein aggregate) grows at the expense of a substrate (protein monomer) in a cyclic reaction characterized by a growth step followed by an increase in template units
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