Frontiers | Machine learning models predicts risk of proliferative lupus nephritis
www.frontiersin.org
In 2003, the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classified LN (7), excluding advanced sclerosing LN (Type VI), into proliferative and non-proliferative types based on renal histopathology. Non-proliferative lupus nephritis (NPLN) includes types I, II, and isolated
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Summary
- 🧬 **Machine Learning Models**: Developed to predict the risk of proliferative lupus nephritis (PLN) in patients with systemic lupus erythematosus (SLE) using various physiological and biochemical indicators.
- 🩺 **Classification of Lupus Nephritis**: Lupus nephritis is classified into proliferative (PLN) and non-proliferative types (NPLN), with PLN being more severe and associated with a higher risk of end-stage renal disease (ESRD).
- 🔍 **Importance of Early Diagnosis**: Rapid diagnosis and targeted treatment for PLN are crucial for improving patient prognosis, but traditional renal biopsy methods can be invasive and risky.
- 📊 **Predictor Variables Identified**: The study identified 11 key predictor variables, including blood pressure, serum creatinine, and anti-dsDNA levels, using logistic regression and LASSO variable selection.
- 🌟 **Non-Invasive Alternatives**: The machine learning models offer promising non-invasive diagnostic methods that could serve as reliable alternatives to renal biopsy, especially for patients who cannot undergo the procedure.
Top Highlights
- In 2003, the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classified LN (7), excluding advanced sclerosing LN (Type VI), into proliferative and non-proliferative types based on renal histopathology.
- Non-proliferative lupus nephritis (NPLN) includes types I, II, and isolated type V, with milder inflammation and renal damage, leading to a favorable prognosis (8)
- Proliferative lupus nephritis (PLN) refers to type III or IV lesions alone or combined with type V lesions (10–12), indicating a more severe condition compared to NPLN, with a significantly increased risk of progression to end-stage renal disease (ESRD) and poor prognosis (13, 14).
- Due to its detrimental impact on renal function and prognosis (14), the treatment strategy for PLN involves overall immunosuppression and maintenance therapy to control inflammation and autoimmune reactions (9)
- Given the differences in treatment strategies and prognosis between PLN and NPLN, rapid diagnosis and early targeted treatment are crucial for improving renal function prognosis, particularly for PLN (9, 15).
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