Frontiers | The effect of combining PD-1 agonist and low-dose Interleukin-2 on treating systemic lupus erythematosus
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PD-1 was initially found in the 2B4.11 clone of apoptotic mouse T cell hybridoma, and its structure was similar to that of CD28 molecule The regulatory T (Treg) cells and effector T (Teff) cells regulate each other to maintain immune homeostasis (11). some studies showed that sPD-1(the soluble form
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- PD-1 was initially found in the 2B4.11 clone of apoptotic mouse T cell hybridoma, and its structure was similar to that of CD28 molecule
- The regulatory T (Treg) cells and effector T (Teff) cells regulate each other to maintain immune homeostasis (11).
- some studies showed that sPD-1(the soluble form of PD-1)played a role in autoimmune inflammation (13).
- Compared with other negative regulators with non-antigen specific characteristics, the absence of PD-1 can affect antigen specific autoimmune response (14).
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