Frontiers | Immune Checkpoints as Therapeutic Targets in Autoimmunity
www.frontiersin.org
Checkpoint agonists that have shown efficacy in treating mouse models of autoimmunity. non-depleting, When the receptor encounters its ligand on an apposing cell the balance of kinase and phosphatase activity is tipped in favor of kinases there is evidence to suggest that the function of inhibitory
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- Checkpoint agonists that have shown efficacy in treating mouse models of autoimmunity.
- non-depleting,
- When the receptor encounters its ligand on an apposing cell the balance of kinase and phosphatase activity is tipped in favor of kinases
- there is evidence to suggest that the function of inhibitory agonists depends on the co-incidence of inhibitory and activating signals within the cell.
- The choice of combinations to use may be guided by the effects seen in double knockout mice.
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