The ability of a pathogen to cause collateral damage to uninfected cells, tissues and organs will also determine disease tropism. This damage may be due to mediators produced by the pathogen [e.g. (Thibeaux et al., 2014)], the activation of non-specific immune responses leading to damage of adjacent cells [e.g. (Almeida-Leite et al., 2007; Schürman...
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