Frontiers | DNA Damage Response and Repair in Adaptive Immunity
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tegrity, which trigger DNA damage response (DDR) by recruiting DDR factors to the DSBs for repairing. ATM and its downstream phosphorylated targets (H2AX, 53BP1, and MDC1) are the key DDR fact o, coding joining is decreased with more un-joined coding ends in ATM-deficient pre-B cells, indicating tha
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- tegrity, which trigger DNA damage response (DDR) by recruiting DDR factors to the DSBs for repairing. ATM and its downstream phosphorylated targets (H2AX, 53BP1, and MDC1) are the key DDR fact
- o, coding joining is decreased with more un-joined coding ends in ATM-deficient pre-B cells, indicating that ATM stabilizes RAG-initiated DSBs during V(D)J recombination (Bredemeyer et al., 2006).
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