Frontiers | Growth Factor Engineering Strategies for Regenerative Medicine Applications
www.frontiersin.org
high levels of proteolytic activity in vivo leads to poor GF stability and short half-life multiple administrations and/or supraphysiological doses are often necessary to sustain an effective concentration of GFs
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- high levels of proteolytic activity in vivo leads to poor GF stability and short half-life
- multiple administrations and/or supraphysiological doses are often necessary to sustain an effective concentration of GFs
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