An evaluation of the combination effect of zoledronate and chemotherapeutic agents in canine osteosarcoma cells
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Osteosarcoma (OSA) is the most common bone tumor in dogs (1). This tumor exhibits locally aggressive and highly metastatic behavior (2). The current standard of care for canine appendicular OSA consists of local therapy (i.e., amputation, surgical limb-spare, or stereotactic radiation therapy) combi
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- Osteosarcoma (OSA) is the most common bone tumor in dogs (1). This tumor exhibits locally aggressive and highly metastatic behavior (2). The current standard of care for canine appendicular OSA consists of local therapy (i.e., amputation, surgical limb-spare, or stereotactic radiation therapy) combined with cytotoxic chemotherapy (i.e., carboplatin...
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