The Crucial Roles of Phospholipids in Aging and Lifespan Regulation thumbnail
The Crucial Roles of Phospholipids in Aging and Lifespan Regulation
www.frontiersin.org
The relationship between lipids and aging has been well recognized. The contents, composition, and metabolism of fatty acid (FA) are altered in aged or long-lived humans and model organisms studies in model organisms such as Caenorhabditis elegans have revealed that various FA species could extend l
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  • The relationship between lipids and aging has been well recognized. The contents, composition, and metabolism of fatty acid (FA) are altered in aged or long-lived humans and model organisms
  • studies in model organisms such as Caenorhabditis elegans have revealed that various FA species could extend lifespan when supplemented in the diet, which includes monosaturated oleic acid, palmitoleic acid, cis-vaccenic acid, and oleoylethanolamine
  • Multiple studies have reported the changes of PC contents as animal ages, with species and tissue specificity.
  • it was reported that the contents of most PCs are notably decreased in the aged nematodes
  • while the accumulation of PCs has been detected in the hippocampus of a brain aging mice model

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