Top Highlights

• The relationship between lipids and aging has been well recognized. The contents, composition, and metabolism of fatty acid (FA) are altered in aged or long-lived humans and model organisms
• studies in model organisms such as Caenorhabditis elegans have revealed that various FA species could extend lifespan when supplemented in the diet, which includes monosaturated oleic acid, palmitoleic acid, cis-vaccenic acid, and oleoylethanolamine
• Multiple studies have reported the changes of PC contents as animal ages, with species and tissue specificity.
• it was reported that the contents of most PCs are notably decreased in the aged nematodes
• while the accumulation of PCs has been detected in the hippocampus of a brain aging mice model

Domain