seudocapillarisation, sinusoidal dysfunction, loss of vasodilatory capacity, and increased hepatic vascular resistanc
. Fenestral diaphragms are comprised of plasmalemma vesicle-associated protein (PLVAP) which is the only known molecular component of these structures
PLVAP forms diaphragms in foetal LSEC and is present during foetal angiogenesis in complex with lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), neuropilin-1 (NRP-1) and vascular endothelial growth factor receptor 2 (VEGFR2)
sinusoidal markers CD32 and intercellular adhesion molecule 1 (ICAM-1) (
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