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• In conclusion, recent data evidenced that ceramides accumulation in brain under lipotoxic conditions might play a role on the deregulation of energy balance and lead to food intake disorders, obesity and the associated perturbation of glucose homeostasis (Table 1). Despite this evidence, the extent and consistency of ceramides effects in specific b...
• A recent study combining lipidomic analysis in mouse models of obesity and in human prospective cohorts evidenced that plasma ceramides were diabetes susceptibility biomarker candidates (Wigger et al., 2017). A deep molecular analysis of the role of ceramide metabolism will help to understand the precise role of these sphingolipids in metabolic dis...
• Sphingolipids metabolism in nervous cells. In mammals, there are two main pathways to produce sphingolipids: (A) the catabolic sphingomylinase pathway that takes place in the lysosomal and plasma membranes and leads to the degradation of sphingomyelin (SM) into ceramides by Sphingomyelinases (SM);
• ndeed, while neuronal activity primarily relies on glucose (lactate, pyruvate), the brain expresses at high level enzymes responsible for the transport, utilization and storage of lipids. It has been demonstrated that discrete neuronal networks in the hypothalamus have the ability to detect variation of circulating long chain fatty acids (FA) to re...
• Recently, different studies suggested that ceramides levels could be involved in the regulation of energy balance in both hypothalamic and extra-hypothalamic areas. Moreover, under lipotoxic conditions, these ceramides could play a role in the dysregulation of glucose homeostasis. In this review we aimed at describing the potential role of ceramide...

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