The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain
www.frontiersin.org
unedited GluA2 does not play a major role in brain function and disease possible role for unedited GluA2 in regulating excitotoxic neuronal cell death in ischemia and ALS This is perhaps surprising given many earlier studies previously ruled out a role for unedited GluA2 in ischemia Arg to a glycine
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- unedited GluA2 does not play a major role in brain function and disease
- possible role for unedited GluA2 in regulating excitotoxic neuronal cell death in ischemia and ALS
- This is perhaps surprising given many earlier studies previously ruled out a role for unedited GluA2 in ischemia
- Arg to a glycine codon (R/G site)
- R/G site, along with the flip/flop, is involved in desensitization and recovery of the receptor, though is not involved in Ca2+-permeability
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