Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
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total sphingomyelin, sulfatide, and GalCer levels were selectively decreased in disease-affected white matter (primary motor cortex), whereas no significant differences were detected in unaffected white matter (visual cortex). αSyn extracted from MSA patient brains mainly appears in the sodium dodec
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- total sphingomyelin, sulfatide, and GalCer levels were selectively decreased in disease-affected white matter (primary motor cortex), whereas no significant differences were detected in unaffected white matter (visual cortex).
- αSyn extracted from MSA patient brains mainly appears in the sodium dodecyl sulfate (SDS)-soluble fraction, whereas αSyn extracted from PD/DLB patient brains appears in the insoluble fraction
- (Peng et al., 2018a). They showed that oligodendrocytes but not neurons transform misfolded αSyn into a strain that has more resistance to PK and stronger transmissibility, which is similar to fibrils obtained from MSA patients, thus highlighting the fact that distinct αSyn strains are generated by different intracellular milieus.
Tags
MSA
aSyn
PD
GM1
neurodegeneration
ganglioside
Domain
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