Functional Micropeptides Encoded by Long Non-Coding RNAs: A Comprehensive Review
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Such micropeptides have been described to be widely involved in life-sustaining activities in several organisms, such as homeostasis regulation, disease, and tumor occurrence, and development, and morphological development of animals, and plants. In this review, we focus on the latest developments i
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- Such micropeptides have been described to be widely involved in life-sustaining activities in several organisms, such as homeostasis regulation, disease, and tumor occurrence, and development, and morphological development of animals, and plants. In this review, we focus on the latest developments in the field of lncRNA-encoded micropeptides, and d...
- LncRNAs have transcriptional length that exceeds 200 nucleotides, being initially defined as “transcriptional noise” (Choi et al., 2019). H
- have short open reading frames (sORFs) encoding micropeptides
- pri-miRNAs and circRNAs also possess sORFs encoding functional micropeptides. I
- sORF-encoded micropeptide SEP in humans which was shown to stimulate DNA double-strand-break junctions by non-homologous end joining and be involved in DNA repai
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