Effects of Carbon Dioxide and Temperature on the Oxygen-Hemoglobin Dissociation Curve of Human Blood: Implications for Avalanche Victims
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of the “triple H syndrome”. This specific combination has several pathophysiological implications, particularly on the cardiovascular system and oxygen transport (oxygen supply and oxygen consumption). vels (20, 40, 60, and 80 mmHg) and five different temperature levels (13.7°C, 23°C, 30°C, 37°C, an
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- of the “triple H syndrome”. This specific combination has several pathophysiological implications, particularly on the cardiovascular system and oxygen transport (oxygen supply and oxygen consumption).
- vels (20, 40, 60, and 80 mmHg) and five different temperature levels (13.7°C, 23°C, 30°C, 37°C, and 42°C), 30 unbuffered whole blood samples were analyzed in a newly developed in vitro method for high-throughput oxygen dissociation curve (ODC) measurements. P50s, Hill coefficients, CO2-Bohr coefficients, and temperature coefficients were analyzed u...
- amine the effects on hemoglobin oxygen affinity, we investigated venous blood samples from 15 female and 15 male healthy subjects. In a factorial design of four different carbon dioxide partial pressure (PCO2) levels (20, 40, 60, and 80 mmHg) and five different temperature level
- e absolute CO2 effect was still pronounced at normothermic and febrile temperatures, whereas at low temperatures, the relative CO2 effect (expressed by CO2-Bohr coefficient; p < 0.001, interaction) was increa
- The larger impact of PCO2 on oxygen affinity at low temperature may be caused by the competition of 2,3-BPG with PCO2 and the exothermic binding characteristic of 2,3-BPG
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