Structural and Functional Features of the P2X4 Receptor: An Immunological Perspective
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stimulation of P2X7 induces a calcium influx, non-selective pore formation, phosphorylation of MAPKinase ERK1/2 and p38, and cell death Extracellular nucleotides are important mediators of activation, triggering various responses through plasma membrane P2 and P1 receptors further subdivided into io
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- stimulation of P2X7 induces a calcium influx, non-selective pore formation, phosphorylation of MAPKinase ERK1/2 and p38, and cell death
- Extracellular nucleotides are important mediators of activation, triggering various responses through plasma membrane P2 and P1 receptors
- further subdivided into ionotropic P2X receptors and G protein-coupled P2Y receptors.
- P2X4 is an ATP-gated cation channel broadly expressed in most tissues of the body
- P2X4 has a unique subcellular distribution, being preferentially localized in lysosomes. In these organelles
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