L-33 activates signaling pathways depending on the myeloid differentiation primary response gene 88 (Myd88) of immune cells expressing the cytokine receptor interleukin 1 receptor-like 1 (ST2) and signals through a heterodimeric receptor complex comprising an IL-33-specific ST2 coupled with the co-receptor IL-1 receptor accessory protein (IL-1 RAcP...
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