Other groups demonstrated that Notch1, together with TGFβ, regulates Foxp3 expression and the maintenance of peripheral iTregs (103). Notch and NF-κB can regulate multiple steps in different T-cell subsets, but neither the mere absence of NF-κB (104) nor the Notch deregulation alone (14) impair numbers and frequencies of the total CD4+ T-cell comp...
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