Phospholipid Scramblases: Role in Cancer Progression and Anticancer Therapeutics
www.frontiersin.org
High PS exposure in cancer cells is triggered by inhibition of ATP-dependent flippases, and activation of scramblases, increased oxidative stress, increased lipid synthesis and altered TME (Koundouros and Poulogiannis, 2020). A scrambled PM with high PS exposure in cancer cells provides an immunosup
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- High PS exposure in cancer cells is triggered by inhibition of ATP-dependent flippases, and activation of scramblases, increased oxidative stress, increased lipid synthesis and altered TME (Koundouros and Poulogiannis, 2020). A scrambled PM with high PS exposure in cancer cells provides an immunosuppressive signal for immunocytes in TME that facili...
- To date, multiple membrane proteins such as PLSCRs, TMEM16F, Xkr8 and GPCR family members are proposed to scramble PM lipids. Ironically these proteins are of different origin and exhibit little homology among themselves
- Unlike other scramblases, PLSCRs and TMEM16 family members exhibit Ca2+-induced non-apoptotic exposure of PS on different cancer cells. PLSCR1 is a 318 aa long, multifunctional type II m
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