Top Highlights

• Endoplasmic reticulum oxidoreductin 1-α (ERO1-α) is an oxidizing enzyme that is enriched in MAMs (Anelli et al., 2012). ERO1-α controls oxidative folding and ER redox homeostasis, and regulates ER Ca2+ flux and subsequent mitochondrial Ca2+ accumulation, which has been reported to be highly expresse
• Mitochondria-associated ER membranes (MAMs) represent a crucial intracellular signaling hub, that regulates various cellular events including Ca2+ homeostasis, lipid metabolism, mitochondrial function, and cellular survival and death. All of these MAM-mediated cellular events contribute to carcinogenesis.
• MAM appears as a crucial platform in autophagosome formation and plays an important role in autophagy. During starvation-induced autophagy, proteins involved in the autophagic machinery process such as ATG5 and ATG14,
• Interestingly, Ca2+ signaling appears to act as an activator and meanwhile as an inhibitor of autophagy
• o the MAM faction from cytosol. Stimulus including extracellular ATP and impaired Ca2+ flux from ER to mitochondria trigger the production of ROS and ultimately activate the NLRP3 inflammasome.

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