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Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy
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Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy Mass spectrometry-based untargeted metabolomic profiling was performed on serum samples of children with either FA alone, asthma alone or both FA and asthma as well as healthy pediatric controls. Specific compariso
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  • Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy
  • Mass spectrometry-based untargeted metabolomic profiling was performed on serum samples of children with either FA alone, asthma alone or both FA and asthma as well as healthy pediatric controls.
  • Specific comparison of FA and asthmatic subjects revealed differences in the microbiota-sensitive aromatic amino acid and secondary bile acid metabolism. Children with both FA and asthma exhibited a metabolomic profile that aligned with that of FA alone but not asthma. Among children with FA, distinct profiles were associated with history of severe...
  • Children with FA display a disease-specific metabolomic profile that is informative of disease mechanisms and severity,
  • metabolomic alterations observed in FA children may reflect the interplay between an altered microbiota and immune cell subsets in the gut.

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