Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy
Mass spectrometry-based untargeted metabolomic profiling was performed on serum samples of children with either FA alone, asthma alone or both FA and asthma as well as healthy pediatric controls.
Specific comparison of FA and asthmatic subjects revealed differences in the microbiota-sensitive aromatic amino acid and secondary bile acid metabolism. Children with both FA and asthma exhibited a metabolomic profile that aligned with that of FA alone but not asthma. Among children with FA, distinct profiles were associated with history of severe...
Children with FA display a disease-specific metabolomic profile that is informative of disease mechanisms and severity,
metabolomic alterations observed in FA children may reflect the interplay between an altered microbiota and immune cell subsets in the gut.
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