This study investigated the effects of Deep Brain Stimulation (DBS) on the functional connectome of Parkinson's Disease (PD) patients. An age-matched control cohort was acquired and DBS lead placement was localized using a state-of-the art pipeline. Global connectivity increases and decreases throughout the brain were estimated by contrasting ON and OFF DBS scans. Local impact of DBS on the motor STN was found to explain half the variance in global connectivity increases within the motor network. Additionally, local impact of DBS on the motor STN could explain the degree of how much voxel-wise average brain connectivity normalized toward healthy controls. Finally, a network based statistics analysis revealed that DBS attenuated specific couplings that are known to be pathological in PD.
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An age-matched control cohort of fifteen subjects was acquired from an open data repository. DBS lead placement in the subthalamic nucleus (STN) was localized using a state-of-the art pipeline that involved brain shift correction, multispectral image registration and use of a precise subcortical atlas. Based on a realistic 3D model of the electrode...
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