Innolysins: A novel approach to engineer endolysins to kill Gram-negative bacteria
www.biorxiv.org
a novel concept for engineering endolysins Innolysins combine the enzymatic activity of endolysins with the binding capacity of phage receptor binding proteins (RBPs). receptor binding protein Pb5 phage receptor FhuA involved in ferrichrome transport in Escherichia coli E. coli fhuA deletion mutant,
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- a novel concept for engineering endolysins
- Innolysins combine the enzymatic activity of endolysins with the binding capacity of phage receptor binding proteins (RBPs).
- receptor binding protein Pb5
- phage receptor FhuA involved in ferrichrome transport in Escherichia coli
- E. coli fhuA deletion mutant, we demonstrated that FhuA is required for bactericidal activity, supporting that the specific binding of Pb5 to its receptor on E. coli is needed for the endolysin to access the peptidoglycan.
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