NeuroFold: A Multimodal Approach to Generating Novel Protein Variants in silico - 2024.03.12.584504v1.full.pdf
www.biorxiv.org
e present NeuroFold, an innovative hybrid model for designing76 enzyme variants with desired traits that incorporates a unique architecture to address the77 limitations of previous methods. NeuroFold goes beyond reliance on a single modality by integrating80 sequence and evolutionary data with struc
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- e present NeuroFold, an innovative hybrid model for designing76 enzyme variants with desired traits that incorporates a unique architecture to address the77 limitations of previous methods.
- NeuroFold goes beyond reliance on a single modality by integrating80 sequence and evolutionary data with structural information.
- Discrimination Module
- The121 Sampling Module is responsible for producing the candidate sequences.
- Discrimination Module is122 responsible for discriminating against functional and non-functional candidates generated by the sampling123 module.
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