CPT1a regulates the delivery of extracellular fatty acids for cardiolipin turnover in prostate cancer cells
www.biorxiv.org
Our observations showed that extracellular LCFAs were not completely oxidised to acetyl-CoA and minimally contributed carbons to the TCA cycle As such, we asked whether there are other pathways that could consume extracellular LCFAs after entering the mitochondria via CPT1a report a reduction of mit
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- Our observations showed that extracellular LCFAs were not completely oxidised to acetyl-CoA and minimally contributed carbons to the TCA cycle
- As such, we asked whether there are other pathways that could consume extracellular LCFAs after entering the mitochondria via CPT1a
- report a reduction of mitochondrial complex lipids in BT549 breast cancer cells with CPT1a knocked down
- As CL remodelling functions to mature nascent CLs by the reacylation from donated acyl-CoAs45, it was conceivable that this process could be a significant consumer of mitochondria LCFA-CoAs
- Collectively, these data demonstrate that PNT1 prostate epithelial and a range of PCa cells rapidly incorporate extracellular LCFAs into CL acyl-chains.
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