In healthy cells, PINK1 is continuously imported into mitochondria, where it is rapidly degraded
However, in unfit mitochondria with a reduced mitochondrial membrane potential (Δψm), PINK1 import stalls.
activates PRKN, enabling it to attach ubiquitin to mitochondrial proteins.
ubiquitination acts as a signal for damaged mitochondria to be identified and engulfed by autophagosome
initiating their degradation through mitophagy. This selective elimination of compromised mitochondria safeguards overall mitochondrial health and function.
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