All-optical reporting of inhibitory receptor driving force in the nervous system thumbnail
All-optical reporting of inhibitory receptor driving force in the nervous system
www.biorxiv.org
astrocytes may serve to continuously supplement anions into the extracellular space during periods of enhanced network activity, and thereby help to maintain the effectiveness of GABAAR-mediated inhibitory synaptic transmission astrocytes continued to exhibit a strongly depolarizing DFGABAA capable
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  • astrocytes may serve to continuously supplement anions into the extracellular space during periods of enhanced network activity, and thereby help to maintain the effectiveness of GABAAR-mediated inhibitory synaptic transmission
  • astrocytes continued to exhibit a strongly depolarizing DFGABAA
  • capable of maintaining a driving force for anion efflux during substantial changes in network activity
  • KCC2 (Slc12a5) was more highly expressed in pyramidal neurons than astrocytes
  • NKCC1 (Slc12a2), although comparatively low in both cell types, exhibited higher expression in astrocytes than pyramidal neurons

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