A previously reported human single-chain variable fragment (scFv) library14 was displayed on the surface of yeast and sorted positively for binding to amyloid fibrils (tau and α-synuclein) via magnetic-activated cell sorting (MACS) and negatively for a lack of binding to the monomeric form of the corresponding amyloid protein (tau or α-synuclein mo...
we observe minimal cross-reactivity of the tau antibodies (ATA1.459.3 or zagotenemab) with α-synuclein conformers, and no observable cross-reactivity of the α-synuclein antibodies (H2.7 or cinpanemab) for any of the tau conformers.
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