Containment is another challenge for homing gene drives as even a small number of drive-carrying individuals are theoretically capable of spreading the drive to an entire population, even if there is a fitness cost to the drive carrier (Esvelt et al., 2014). This means that a drive would likely impact non-target populations, creating significant ec...
Identifying suitable target fertility genes is also a critical step in investigating and understanding the complex molecular challenges that can arise during gene drive development
A more practical approach is to identify and disrupt a functionally important gene region with a specific role in fertility. An ideal target would be a haplosufficient gene essential for fertility in one sex, such that the other sex can transmit the drive further.
Evidence of a complete sex-biased fertility phenotype is required to permit the opposite sex to transmit the drive.
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