A common observation across species and sensory modalities is that novel stimuli evoke larger sensory responses compared to familiar stimuli
At the population level, the direction of these changes is consistent with engagement of the Vip-Sst disinhibitory circui
three forms of novelty
During imaging, active behavior sessions were interleaved with passive viewing sessions where mice viewed the stimulus in open loop mode with the lick spout removed after mice had received their daily water.
Symbols on y-axis indicate cell population labeled with GCaMP6f in each mouse; square: Excitatory, triangle: Sst Inhibitory, circle: Vip Inhibitory
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