A Borrelia burgdorferi LptD Homolog Facilitates Flipping of Surface Lipoproteins Through the Spirochetal Outer Membrane
www.biorxiv.org
β -barrel domain expanded to 28 antiparallel β -strands Upon BB0838 knockdown, sentinel surface lipoprotein OspA Borrelia burgdorferi BB0838, a distant homolog of the OM LPS assembly protein LptD. B. burgdorferi beta-barrel assembly machinery (BAM) protein BamA led to a significant growth defect and
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- β -barrel domain expanded to 28 antiparallel β -strands
- Upon BB0838 knockdown, sentinel surface lipoprotein OspA
- Borrelia burgdorferi BB0838, a distant homolog of the OM LPS assembly protein LptD.
- B. burgdorferi beta-barrel assembly machinery (BAM) protein BamA led to a significant growth defect and also reduced the abundance of surface lipoproteins in the OM
- non-toxic CRISPR interference (CRISPRi) system (Murphy et al., 2022).
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