Thus, targeting the MPS could be an effective strategy to enhance checkpoint blockade efficacy and promote control of tumors. Here, we found that protein kinase C delta (PKCδ), a serine/threonine kinase, is abundantly expressed by mononuclear phagocytes in several human and mouse tumors
Thus, PKCδ might be targeted to reprogram mononuclear phagocytes and augment checkpoint blockade efficacy.
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