Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer thumbnail
Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer
www.biorxiv.org
Thus, targeting the MPS could be an effective strategy to enhance checkpoint blockade efficacy and promote control of tumors. Here, we found that protein kinase C delta (PKCδ), a serine/threonine kinase, is abundantly expressed by mononuclear phagocytes in several human and mouse tumors Thus, PKCδ m
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  • Thus, targeting the MPS could be an effective strategy to enhance checkpoint blockade efficacy and promote control of tumors. Here, we found that protein kinase C delta (PKCδ), a serine/threonine kinase, is abundantly expressed by mononuclear phagocytes in several human and mouse tumors
  • Thus, PKCδ might be targeted to reprogram mononuclear phagocytes and augment checkpoint blockade efficacy.

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