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Metabolic adaptation to progressive mitochondrial dysfunction in aging POLGD257A mice
www.biorxiv.org
Increased glycolysis and gluconeogenesis Similar to patients diagnosed with POLG mutations Polg mice were hypoglycemic with fasting blood glucose levels that were significantly decreased relative to WT mice plasma glucose cleared more rapidly in Polg compared to WT mice fasting plasma glucagon level
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Increased glycolysis and gluconeogenesis
Similar to patients diagnosed with POLG mutations
Polg mice were hypoglycemic with fasting blood glucose levels that were significantly decreased relative to WT mice
plasma glucose cleared more rapidly in Polg compared to WT mice
fasting plasma glucagon levels were significantly increased in Polg mice compared to WT mice
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www.biorxiv.org
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