show that a low-complexity Variational Auto-encoder (VAE) can interpolate in sequence space to produce diverse and novel capsids capable of packaging their own genomes
select a 28 amino acid window near the heparin binding site
experimental data we use consists of 36,562 variants of AAV2 (substitution only) mutants of which 22,704 we classified as viable
(i) Evolutionary data (MSA) alone (n=564) (ii) Evolutionary data supplemented 667 randomly generated viable variants (MSAr) from a deep mutational exploration (n=1,231) and finally (iii) Evolutionary data augmented by 22,704 viable (MSA+) mutants 1-21 mutations from wildtype generated at random or an additive model (n=23,268)
viral variants likely capable of generating functional assemblies
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