Assume that the larger the amplitude of positive effect of *anything*, the larger the amplitude of side effects, whether they are known or unknown. This could apply to modafinil or a high-octane macchiato.
If you take something exogenously (originating from outside an organism; think “exo” of exoskeleton) that your body produces endogenously (originating from inside an organism), your body—in its infinite wisdom—will reduce or stop producing said something. Endocrinology abhors waste
“When we try to pick out anything by itself, we find it hitched to everything else in the Universe.” — John Muir
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