The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats - Psychopharmacology
link.springer.com
Inactivation of either the SN or the VTA greatly reduced responding on the active lever. A previous study has shown that inhibiting DA cell impulse activity via DA autoreceptor activation reduced cocaine seeking (Marinelli et al. 2003). The attenuation of responding after SN inactivation is unlikely
1 Users
0 Comments
2 Highlights
0 Notes
Top Highlights
- Inactivation of either the SN or the VTA greatly reduced responding on the active lever. A previous study has shown that inhibiting DA cell impulse activity via DA autoreceptor activation reduced cocaine seeking (Marinelli et al. 2003). The attenuation of responding after SN inactivation is unlikely to have been due to simple motor inhibition, base...
- Because the SN provides the primary input of DA into the dlCPu, the finding that SN inactivation blocks reinstatement without adversely affecting spontaneous locomotion behavior further supports a critical role of dlCPu DA in relapse behavior.
Domain
Ready to highlight and find good content?
Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.