Optogenetic silencing hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of working memory thumbnail
Optogenetic silencing hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of working memory
elifesciences.org
The illuminated trials had the arms pseudo-randomized, ensuring a balanced distribution of left and right sample arms (50% each), and restricted to allow a maximum of 3 consecutive trials. This indicates that the effect of hippocampal terminal silencing in RSC during TI trials affected interleaved N
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  • The illuminated trials had the arms pseudo-randomized, ensuring a balanced distribution of left and right sample arms (50% each), and restricted to allow a maximum of 3 consecutive trials.
  • This indicates that the effect of hippocampal terminal silencing in RSC during TI trials affected interleaved NI trials, thus spreading beyond illumination.
  • Furthermore, we asked whether our manipulation would prevent error-corrective behavior, in which animals use action-outcome information after an error trial (i.e., absence of reward),
  • This observation suggests that such persistent disruption is caused by synaptic plasticity events related to preceding neural activity affected by the optogenetic manipulation

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