The illuminated trials had the arms pseudo-randomized, ensuring a balanced distribution of left and right sample arms (50% each), and restricted to allow a maximum of 3 consecutive trials.
This indicates that the effect of hippocampal terminal silencing in RSC during TI trials affected interleaved NI trials, thus spreading beyond illumination.
Furthermore, we asked whether our manipulation would prevent error-corrective behavior, in which animals use action-outcome information after an error trial (i.e., absence of reward),
This observation suggests that such persistent disruption is caused by synaptic plasticity events related to preceding neural activity affected by the optogenetic manipulation
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