Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
elifesciences.org
Among these drugs was SNC80, a small molecule drug originally developed as a nonaddictive pain reliever that acts independently of the mu-opioid pathway.12 This drug caught our attention because it has been shown to induce hypothermia and protect against the effects of spinal cord ischemia in rodent
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- Among these drugs was SNC80, a small molecule drug originally developed as a nonaddictive pain reliever that acts independently of the mu-opioid pathway.12 This drug caught our attention because it has been shown to induce hypothermia and protect against the effects of spinal cord ischemia in rodents.
- Specifically, reduced functionality of the mitochondrial electron transport chain system without the endogenous antioxidant and anti-inflammatory molecules released by hibernators can result in the release of reactive oxygen species and cause tissue damage.8
- Several molecular strategies have been proposed to achieve metabolic suppression for organ preservation, including modulating H2S, AMPK, opioid receptors, microRNAs, HO-1, and Nrf2.8 H2S exposure has been reported to induce a hypometabolic state (reduced metabolism and body temperature) in a rodent model
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