Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting
elifesciences.org
IF enhances stress-induced cardiac performance fasting cycles are highly and consistently effective in protecting against cardiovascular diseases and improving cardiac health in animals and human IF regimens significantly affected pathways that regulate cyclic GMP signaling, lipid and amino acid met
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- IF enhances stress-induced cardiac performance
- fasting cycles are highly and consistently effective in protecting against cardiovascular diseases and improving cardiac health in animals and human
- IF regimens significantly affected pathways that regulate cyclic GMP signaling, lipid and amino acid metabolism, cell adhesion, cell death, and inflammation
- higher correlation of pathway alternation in short IF regimen but the inverse correlation of metabolic processes such as fatty acid oxidation and immune processes in longer IF regimens
- distinct molecular adaptations of the heart to different intermittent fasting regimens
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