The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
elifesciences.org
aims to identify non-invasive interventions that extend lifespan and promote healthy ageing F2 offspring are derived from inbred grandparents with known linkage phase and have relatively large allelic variation main objective of studies using the Het3 population has been to identify interventions wi
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Summary
Integrating human and mouse discovery platforms has the potential to advance our understanding of cardiometabolic diseases. By combining data from both species, researchers can identify common pathways and potential therapeutic targets. Mouse models can also be used to validate findings from human studies and test new treatments. This approach has already led to the development of several successful drugs for cardiometabolic diseases, and continued integration of human and mouse research could lead to even more breakthroughs in the future.
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- aims to identify non-invasive interventions that extend lifespan and promote healthy ageing
- F2 offspring are derived from inbred grandparents with known linkage phase and have relatively large allelic variation
- main objective of studies using the Het3 population has been to identify interventions with robust effects across a range of genetic backgrounds
- panel has also been used to map QTLs for various traits
- Het3 mice have mostly been utilised for the identification of potential anti-ageing compounds, several of which (e.g. metformin, rapamycin, acarbose, canagliflozin) were reported to have a favourable impact on metabolic profile and other cardiometabolic-related traits, though often in a sex-dependent manner
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