The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts
elifesciences.org
However, the mutants are hypersensitive to heat, drought, oxidative, and salt stress and over-accumulate cytoplasmic protein aggregates (Zhou et al., 2013). Kikuchi YNakamura SWoodson JDIshida HLing QHidema JJarvis RPHagihara SIzumi M (2020) Chloroplast autophagy and ubiquitination combine to manage
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Summary
This study investigates the role of the autophagy receptor NBR1 in the clearance of photodamaged chloroplasts. The researchers found that NBR1 coats both the surface and interior of chloroplasts and is involved in their degradation. They also discovered that NBR1 interacts with other proteins, such as SQSTM1, through specific domains. Arabidopsis mutants lacking NBR1 showed hypersensitivity to various stresses and accumulated protein aggregates. Overall, this research provides insights into the mechanisms of chloroplast autophagy and its importance in managing oxidative damage and stress responses in plants.
Top Highlights
- However, the mutants are hypersensitive to heat, drought, oxidative, and salt stress and over-accumulate cytoplasmic protein aggregates (Zhou et al., 2013).
- Kikuchi YNakamura SWoodson JDIshida HLing QHidema JJarvis RPHagihara SIzumi M (2020) Chloroplast autophagy and ubiquitination combine to manage oxidative damage and starvation responses Plant Physiology 183:1531–1544. https://doi.org/10.1104/pp.20.00237 PubMed Google Scholar
- photodamaged chloroplasts lose envelope integrity, cytosolic ligases reach the chloroplast interior
- independently of ATG7
- intense light
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