Arginase 1 is a key driver of immune suppression in pancreatic cancer thumbnail
Arginase 1 is a key driver of immune suppression in pancreatic cancer
elifesciences.org
Immunosuppressive macrophages are classically defined by the expression of the enzyme Arginase 1 (ARG1), which we demonstrated is potently expressed in pancreatic tumor-associated macrophages from both human patients and mouse models.
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  • Immunosuppressive macrophages are classically defined by the expression of the enzyme Arginase 1 (ARG1), which we demonstrated is potently expressed in pancreatic tumor-associated macrophages from both human patients and mouse models.

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