Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism
elifesciences.org
Thus, to identify its interbacterial defense factors, we subjected a transposon library of P. aeruginosa to antagonism by B. thai or a derivative lacking antibacterial T6SS activity (ΔT6S) and used high-throughput sequencing to measure gene-level fitness changes. These findings liken the response of
1 Users
0 Comments
26 Highlights
8 Notes
Top Highlights
- Thus, to identify its interbacterial defense factors, we subjected a transposon library of P. aeruginosa to antagonism by B. thai or a derivative lacking antibacterial T6SS activity (ΔT6S) and used high-throughput sequencing to measure gene-level fitness changes.
- These findings liken the response of P. aeruginosa to bacterial threats to that of eukaryotic innate immunity, wherein threat detection leads to the activation of specialized defense systems.
- the production of immunity proteins that grant protection against specific toxins delivered by the type VI secretion system (T6SS) (Ross et al., 2019).
- envelope integrity
- While the P. aeruginosa genes identified impacted survival when the toxin was produced heterologously within the organism, they did not influence the fitness of the bacterium during interbacterial competition with V. cholerae.
Domain
Ready to highlight and find good content?
Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.