SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
elifesciences.org
This identifies a novel mechanism by which SARS-CoV-2 host-shutoff antagonises innate immunity. Depletion of spike-specific antibodies confirmed their dominant role in neutralisation, but these antibodies played only a minor role in ADNKA compared to antibodies to other proteins, including ORF3a, Me
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- This identifies a novel mechanism by which SARS-CoV-2 host-shutoff antagonises innate immunity.
- Depletion of spike-specific antibodies confirmed their dominant role in neutralisation, but these antibodies played only a minor role in ADNKA compared to antibodies to other proteins, including ORF3a, Membrane, and Nucleocapsid.
- Later in the disease process, strong antibody-dependent NK cell activation (ADNKA) developed.
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