The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila
elifesciences.org
By contrast, two putative uORFs in the 5’ leader of the long splice isoforms of Xrp1 (e.g. isoform F and G) were identified, with uORF1 predicted to encode a 124 a.a. length peptide, and the uORF2 with a 288 a.a. peptide. This approach did not detect initiation codons in the 5’ leader of Xrp1’s shor
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- By contrast, two putative uORFs in the 5’ leader of the long splice isoforms of Xrp1 (e.g. isoform F and G) were identified, with uORF1 predicted to encode a 124 a.a. length peptide, and the uORF2 with a 288 a.a. peptide.
- This approach did not detect initiation codons in the 5’ leader of Xrp1’s shorter splice isoforms (e.g. isoform D and E).
- The phylogenetic conservation of D. melanogaster uORF2 at the peptide level supports the idea that this is a functional uORF that has been under selective pressure during evolution.
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