DunedinPACE, a DNA methylation biomarker of the pace of aging
elifesciences.org
ongitudinal changes in 19 biomarkers assessing cardiovascular, metabolic, renal, hepatic, immune, dental, and pulmonary systems, measured at ages 26, 32, 38 and, most recently in 2019, 45 years resulting Pace of Aging was then scaled to a mean of 1, so that it could be interpreted with reference to
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- ongitudinal changes in 19 biomarkers assessing cardiovascular, metabolic, renal, hepatic, immune, dental, and pulmonary systems, measured at ages 26, 32, 38 and, most recently in 2019, 45 years
- resulting Pace of Aging was then scaled to a mean of 1, so that it could be interpreted with reference to an average rate of 1 year of biological aging per year of chronological aging
- aging represents progressive decline across organ systems, we calculated each Study member’s Pace of Aging as the sum of age-dependent annual changes across all biomarkers: Pace of Aging
- Study members showed wide variation in their Pace of Aging (Mean = 1 biological year per chronological year, SD = 0.29
- two decades that we measured biological aging
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